NTP CHEMICAL REPOSITORY
SODIUM DODECYL SULFATE

 

-IDENTIFIERS
 ===========

 

*CATALOG ID NUMBER: 000597

 

*CAS NUMBER: 151-21-3

 

*BASE CHEMICAL NAME: SODIUMDODECYLSULFATE

 

*PRIMARY NAME: SODIUM DODECYL SULFATE

 

*CHEMICAL FORMULA: C12H25O4S.Na

 

*STRUCTURAL FORMULA: CH3(CH2)11OSO3Na

 

*WLN: WSQO12 &-NA-

 

*SYNONYMS:
  SULFURIC ACID, MONODODECYL ESTER, SODIUM SALT
  DODECYL ALCOHOL, HYDROGEN SULFATE, SODIUM SALT
  DODECYL SODIUM SULFATE
  DODECYL SULFATE SODIUM
  LAURYL SODIUM SULFATE
  SODIUM LAURYL SULFATE
  AKYPOSAL SDS
  AQUAREX ME
  AQUAREX METHYL
  AVIROL 101
  AVIROL 118 CONC
  BEROL 452
  CARSONOL SLS
  CARSONOL SLS PASTE B
  CARSONOL SLS SPECIAL
  CONCO SULFATE WA
  CONCO SULFATE WA-1200
  CONCO SULFATE WA-1245
  CONCO SULFATE WAG
  CONCO SULFATE WAN
  CONCO SULFATE WAS
  CONCO SULFATE WN
  CYCLORYL 21
  CYCLORYL 31
  CYCLORYL 580
  CYCLORYL 585N
  DEHAG SULFATE GL EMULSION
  DEHAG SULPHATE GL EMULSION
  DETERGENT 66
  N-DODECYL SULFATE SODIUM
  DODECYL SULFATE, SODIUM SALT
  DREFT
  DUPONAL WAQE
  DUPANAL
  DUPONOL
  DUPONOL C
  DUPONOL ME
  DUPONOL METHYL
  DUPONOL QX
  DUPONOL WA
  DUPONOL WA DRY
  DUPONOL WAQ
  DUPONOL WAQA
  DUPONOL WAQE
  DUPONOL WAQM
  EMAL O
  EMAL 10
  EMERSAL 6400
  EMPICOL LPZ
  EMPICOL LS 30
  EMPICOL LX 28
  EMULSIFIER NO. 104
  FINASOL OSR (SUB 2)
  GARDINOL
  HEXAMOL SLS
  IRIUM
  LANETTE WAX-S
  LAURYL SULFATE, SODIUM SALT
  MAPROFIX 563
  MAPROFIX LK
  MAPROFIX NEU
  MAPROFIX WAC
  MAPROFIX WAC-LA
  MELANOL CL
  MELANOL CL 30
  MONODODECYL SODIUM SULFATE
  MONOGEN Y 100
  MONTOPOL LA PASTE
  NCI-C50191
  NEUTRAZYME
  NIKKOL SLS
  ODORIPON AL 95
  ORVUS WA PASTE
  P AND G EMULSIFIER 104
  PERLANDROL L
  PRODUCT NO. 75
  PRODUCT NO. 161
  QUOLAC EX-UB
  REWOPOL NLS 30
  RICHONOL A
  RICHONOL AF
  RICHONOL C
  SINNOPON LS 95
  SINNOPON LS 100
  SINTAPON L
  SIPEX OP
  SIPEX SB
  SIPEX SD
  SIPEX SP
  SIPEX UB
  SIPON LS
  SIPON LS 100
  SIPON LSB
  SIPON PD
  SIPON WD
  SLS
  SODIUM DOCECYL SULFATE
  SODIUM N-DODECYL SULFATE
  SODIUM DODECYL SULPHATE
  SODIUM LAURYL SULPHATE
  SODIUM MONODODECYL SULFATE
  SODIUM MONOLAURYL SULFATE
  SOLSOL NEEDLES
  STANDAPOL 112 CONC
  STEINAPOL NLS 90
  STEPANOL ME
  STERLING WA PASTE
  SULFETAL L 95
  SULFOPON WA 1
  SULFOTEX WA
  SWASCOL 3L
  SYNTAPON
  TARAPON K 12
  TEXAPON DL CONC.
  TREPENOL WA
  TVM 474
  ULTRA SULFATE SL-1
  WAQE

 

-PHYSICAL CHEMICAL DATA
 ======================

 

*PHYSICAL DESCRIPTION: LITERATURE: White to cream-colored crystals, flakes or
                                    powder
                       REPOSITORY: White powder

 

*MOLECULAR WEIGHT: 288.38

 

*SPECIFIC GRAVITY: Not available

 

*DENSITY: Not available

 

*MP (DEG C): 204-207 C [055,269]

 

*BP (DEG C): Not available

 

*SOLUBILITIES:
       WATER : <1 mg/mL @ 19 C (RAD)

 

        DMSO : 10-50 mg/mL @ 19 C (RAD)

 

 95% ETHANOL : <1 mg/mL @ 19 C (RAD)

 

    METHANOL : 5-10 mg/mL @ 17 C (RAD)

 

     ACETONE : <1 mg/mL @ 19 C (RAD)

 

     TOLUENE : <1 mg/mL @ 17 C (RAD)

 

 OTHER SOLVENTS:
  Alcohol: Partly soluble [295]
  Chloroform: Practically insoluble [295]
  Ether: Practically insoluble [295]
  Light petroleum: Practically insoluble [295]

 

*VOLATILITY:
    Vapor pressure: Not available
    Vapor density : Not available

 

*FLAMMABILITY(FLASH POINT):
      Flash point data for this chemical are not available; however, it is
 probably combustible.  Fires involving this material can be controlled with
 a dry chemical, carbon dioxide or Halon extinguisher.  A water spray may also
 be used [058].

 

*UEL: Not available                         LEL: Not available

 

*REACTIVITY:
      This chemical has neutral reactions [031,051].  It is incompatible
 with strong oxidizers [058,269].  It is also incompatible with cationic
 materials and with acids with pH below 2.5 [295].

 

*STABILITY:
      This chemical is stable under normal laboratory conditions [058].
 Solutions of this chemical in water, DMSO, 95% ethanol or acetone should
 be stable for 24 hours under normal lab conditions (RAD).

 

*OTHER PHYSICAL DATA:
  Melting point also reported as 184-185 C [052]
  Endotherms occur @ 60 C, 81-88 C, 204 C, 211 C and 226 C [052]
  log P octanol: 1.60 [055]
  Smooth feel [031,051]
  Forms an opalescent solution in water [031,051,062]
  Lowers the surface tension of aqueous solutions [031,051]
  Emulsifies fats [031,051]
  Faint odor of fatty substances [031,051,058]

 

-TOXICITY
 ========

 

*NIOSH REGISTRY NUMBER: WT1050000

 

*TOXICITY: (abbreviations)
        typ. dose    mode     specie      amount     units     other
          LD50       orl       rat         1288      mg/kg
          LD50       ipr       rat          210      mg/kg
          LD50       ivn       rat          118      mg/kg
          LD50       ipr       mus          250      mg/kg
          LD50       ivn       mus          118      mg/kg

 

*AQTX/TLM96: Not available

 

*SAX TOXICITY EVALUATION:
  THR: Poison by intravenous and intraperitoneal routes.  Moderately toxic
       by ingestion.  An experimental teratogen.  Experimental reproductive
       effects.  A human skin irritant.  An experimental eye and severe skin
       irritant.  A mild allergen.  Mutagenic data.

 

*CARCINOGENICITY: Not available

 

*MUTATION DATA:
       test          lowest dose      |      test          lowest dose
    -----------   -----------------   |   -----------   -----------------
    mmo-omi          200 mg/L         |   mmo-smc         3500 umol/L
    sln-asn          900 ppm          |   dni-gpg:kdy       60 umol/L

 

*TERATOGENICITY:
  Reproductive Effects Data:
    TDLo: skn-mus  480 mg/kg (6-13D preg)

 

*STANDARDS, REGULATIONS & RECOMMENDATIONS:
  OSHA: None
  ACGIH: None
  NIOSH Criteria Document: None
  NFPA Hazard Rating: Health (H): None
                      Flammability (F): None
                      Reactivity (R): None

 

*OTHER TOXICITY DATA:
  Skin and Eye Irritation Data:
    skn-hmn   250 mg/24H MLD
    skn-hmn    25 mg/24H MLD
    skn-dog    25 mg/24H MLD
    skn-rbt    25 mg/24H MOD
    skn-rbt   250 mg/24H MOD
    skn-rbt    10 mg/24H
    skn-rbt    50 mg/24H MLD
    eye-rbt     2 mg
    skn-pig    25 mg/24H MLD
    skn-gpg    25 mg/24H MLD
    skn-mus    25 mg/24H MOD
    skn-rbt    50 mg/24H SEV
    eye-rbt   100 mg/24H MOD
    eye-rbt    10 mg MOD
    eye-rbt   250 ug MLD
  Review: Toxicology Review
  Status: EPA TSCA Chemical Inventory, 1986
          EPA TSCA Test Submission (TSCATS) Data Base, June 1989
          Meets criteria for proposed OSHA Medical Records Rule

 

-OTHER DATA (Regulatory)
 =======================

 

*PROPER SHIPPING NAME (IATA): Other regulated substances

 

*UN/ID NUMBER: ID8027

 

*HAZARD CLASS: 9             SUBSIDIARY RISK: None    PACKING GROUP: None

 

*LABELS REQUIRED: Miscellaneous

 

*PACKAGING: PASSENGER: PKG. INSTR.: 906             MAXIMUM QUANTITY: No
limit
            CARGO    : PKG. INSTR.: 906             MAXIMUM QUANTITY: No limit

 

*SPECIAL PROVISIONS: None

 

*USES:
      This compound is used as a wetting agent in textiles, as a detergent
 (sometimes in toothpastes), as a food additive, as a surfactant, as an
 emulsifier and as a thickener.  It can be used in hard water.

 

*COMMENTS: Not available

 

-HANDLING PROCEDURES
 ===================

 

*ACUTE/CHRONIC HAZARDS:
      This comopund is an irritant of the skin, eyes and respiratory tract
 [058,099,295].  When heated to decomposition it emits toxic fumes of carbon
 monoxide, carbon monoxide, hydrogen sulfide and sulfur oxides [043,058,269].

 

*MINIMUM PROTECTIVE CLOTHING: Not available

 

*RECOMMENDED GLOVE MATERIALS:
 GlovES+ Expert System Glove Types For The Neat (Undiluted) Chemical:
      This chemical has not been tested for permeation by Radian Corporation;
 however, the GlovES+ expert system was used to extrapolate permeation test
 information from compounds in the same chemical class.  The GlovES+ system uses
 permeation data from literature sources; therefore, extra safety margins should
 be used with the estimated protection time(s).  If this chemical makes direct
 contact with your glove, or if a tear, puncture or hole develops, replace them
 at once.
      The GlovES+ expert system is a tool that can help people better manage
 protection from chemicals, however this tool cannot replace sound judgment nor
 make technical decisions.  Our GlovES+ expert system is designed to offer
 initial advice and assistance in glove selection while the final glove
 selection should be made by knowledgeable individuals based on the specific
 circumstances involved.

 

 Glove Type            Model Number      Thickness   Estimated Protection Time
 Butyl rubber          North B-174        0.68 mm            480 min
 Nitrile               Edmont 37-155      0.35 mm            480 min
 Neoprene              Edmont 29-840      0.28 mm            480 min
 PVC                   Edmont 34-100      0.14 mm            240 min

 

*RECOMMENDED RESPIRATOR:
      Where the neat test chemical is weighed and diluted, wear a NIOSH-
 approved half face respirator equipped with an organic vapor/acid gas
 cartridge (specific for organic vapors, HCl, acid gas and SO2) with a
 dust/mist filter.

 

*OTHER: Not available

 

*STORAGE PRECAUTIONS:
      You should store this chemical under ambient temperatures,
 and keep it away from oxidizing materials.

 

*SPILLS AND LEAKAGE:
      If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION.  You
 should then dampen the solid spill material with 60-70% methanol, then transfer
 the dampened material to a suitable container.  Use absorbent paper dampened
 with methanol to pick up any remaining material.  Your contaminated clothing
 and absorbent paper should be sealed in a vapor-tight plastic bag for eventual
 disposal.  Solvent-wash contaminated surfaces with 60-70% methanol followed by
 washing with a soap and water solution.  Do not reenter the contaminated area
 until the Safety Officer (or other responsible person) has verified that the
 area has been properly cleaned.

 

*DISPOSAL AND WASTE TREATMENT: Not available

 

-EMERGENCY PROCEDURES
 ====================

 

*SKIN CONTACT:
      IMMEDIATELY flood affected skin with water while removing and isolating
 all contaminated clothing.  Gently wash all affected skin areas thoroughly
 with soap and water.
      If symptoms such as redness or irritation develop, IMMEDIATELY call a
 physician and be prepared to transport the victim to a hospital for treatment.

 

*INHALATION:
      IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
 If symptoms (such as wheezing, coughing, shortness of breath, or burning in
 the mouth, throat, or chest) develop, call a physician and be prepared to
 transport the victim to a hospital.
      Provide proper respiratory protection to rescuers entering an unknown
 atmosphere.  Whenever possible, Self-Contained Breathing Apparatus (SCBA)
 should be used; if not available, use a level of protection greater than or
 equal to that advised under Respirator Recommendation.

 

*EYE CONTACT:
      First check the victim for contact lenses and remove if present.  Flush
 victim's eyes with water or normal saline solution for 20 to 30 minutes while
 simultaneously calling a hospital or poison control center.
      Do not put any ointments, oils, or medication in the victim's eyes without
 specific instructions from a physician.
      IMMEDIATELY transport the victim after flushing eyes to a hospital even if
 no symptoms (such as redness or irritation) develop.

 

*INGESTION:
      DO NOT INDUCE VOMITING.  If the victim is conscious and not convulsing,
 give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a
 hospital or poison control center.  Be prepared to transport the victim to a
 hospital if advised by a physician.
      If the victim is convulsing or unconscious, do not give anything by mouth,
 ensure that the victim's airway is open and lay the victim on his/her side with
 the head lower than the body.  DO NOT INDUCE VOMITING.  IMMEDIATELY
transport
 the victim to a hospital.

 

*SYMPTOMS:
      Symptoms of exposure to this compound include irritation of the skin
 with rash, irritation of the eyes with redness and pain, irritation of the
 nose, throat and respiratory tract, gastrointestinal distress, nausea,
 diarrhea, sore throat, coughing and choking [058].  It may also cause mild
 skin allergies [051].

 

-SOURCES
 =======

 

*SOURCES:
 [015] Lewis, R.J., Sr. and R.L. Tatken, Eds.  Registry of Toxic Effects
          of Chemical Substances.  On-line Ed.  National Institute for
          Occupational Safety and Health.  Cincinnati, OH.  WT1050000.
          December 4, 1989.

 

 [031] Windholz, M., Ed.  The Merck Index.  10th Ed.  Merck and Co.
          Rahway, NJ.  1983.  p. 1237, #8474.

 

 [043] Sax, N.I. and Richard J. Lewis, Sr.  Dangerous Properties of Industrial
          Materials.  7th Ed.  Van Nostrand Reinhold.  New York.  1989.
          Vol. III, p. 3150, #SDN500.

 

 [051] Sax, N. Irving, Ed.  Dangerous Properties of Industrial Materials
          Report.  Bi-monthly Updates.  Van Nostrand Reinhold Company, Inc.
          New York.  January/February 1982.  Vol. 2, No. 1, p. 117.

 

 [052] Midwest Research Institute.  MRI Report for Sodium dodecyl sulfate.
          Kansas City, MO.  May 12, 1975.

 

 [055] Verschueren, K.  Handbook of Environmental Data on Organic
          Chemicals.  2nd Ed.  Van Nostrand Reinhold.  New York.  1983.
          p. 793.

 

 [058] Information Handling Services.  Material Safety Data Sheets
          Service.  Microfiche Ed.  Bimonthly Updates.  December 1989/
          January 1990.  #5846-076, A-01.

 

 [062] Sax, N.I. and R.J. Lewis Sr., Eds.  Hawley's Condensed Chemical
          Dictionary.  11th Ed.  Van Nostrand Reinhold.  New York.  1987.
          p. 1064.

 

 [082] U.S. Environmental Protection Agency, Office of Toxic Substances.
          Toxic Substances Control Act Chemical Substance Inventory:  1985
          Edition.  5 Vols.  U.S. Environmental Protection Agency.
          Washington, D.C.  January 1986.  Listed.

 

 [099] Grant, W. Morton, M.D.  Toxicology of the Eye.  3rd Ed.  Charles
          C. Thomas, Publisher.  Springfield, IL.  1986.  p. 871.

 

 [110] Oak Ridge National Laboratory.  Environmental Mutagen Information
          Center (EMIC), Bibliographic Data Base.  Oak Ridge National
          Laboratory.  Oak Ridge, TN.  Listed.

 

 [120] Oak Ridge National Laboratory.  Environmental Teratogen Information
          Center (ETIC), Bibliographic Data Base.  Oak Ridge National
          Laboratory.  Oak Ridge, TN.  Not listed.

 

 [151] Gosselin, R.E., H.C. Hodge, and R.P. Smith.  Clinical Toxicology
          of Commercial Products.  5th Ed.  Williams and Wilkins, Co.
          Baltimore.  1984.  p. II-274, #946.

 

 [195] Estrin, F.E., P.A. Crosley and C.R. Haynes, Eds.  CFTA Cosmetic
          Ingredient Dictionary.  3rd Ed.  The Cosmetic, Toiletry and
          Fragrance Assn. Inc.  Washington.  1982.  p. 285.

 

 [269] Lenga, Robert E.  The Sigma-Aldrich Library of Chemical Safety Data.
          Edition 1.  Sigma-Aldrich Corporation.  Milwaukee, WI.  1985.
          p. 847, #C.

 

 [275] Aldrich Chemical Company.  Aldrich Catalog/Handbook of Fine
          Chemical.  Aldrich Chemical Co., Inc.  Milwaukee, WI.
          1988.  p. 662, #85,192-2.

 

 [295] Reynolds, James E.F., Ed.  Martindale The Extra Pharmacopoeia.  28th Ed.
          The Pharmaceutical Press.  London.  1982.  p. 1442.

 

 [406] Goodman, L.S., A. Gilman, F. Murad and T.W. Rall, Eds.  The
          Pharmacological Basis of Therapeutics.  7th Ed.  Macmillan
          Publishing Co.  New York.  1985.  p. 947.

 

 [610] Clansky, Kenneth B., Ed.  Suspect Chemicals Sourcebook:  A Guide to
          Industrial Chemicals Covered Under Major Federal Regulatory and
          Advisory Programs.  Roytech Publications, Inc.  Burlingame, CA.
          1990.  Section 3, p. 60.

 

 [620] United States National Toxicology Program.  Chemical Status Report.
          NTP Chemtrack System.  Research Triangle Park, NC.  November 6, 1990.
          Listed.